This really helped me understand a bit more about the differences between AlphaFold1 to AlphaFold2 and RosettaTR to RoseTTAFold respectively. Very cool, if somewhat long talk (well its a seminar ^^).
Particularly interesting is the performance comparison between the different version of RoseTTAFold and AlphaFold2 as illustrated on this slide of the presentation :
I guess I will have to give RoseTTAFold a try, especially since its supposedly less resource hungry. And maybe a little bit less of hazzle to install (if you do not have the luxury of just using docker on your computational infrastructure, … so like in most HPC environments …)